Download e-book for iPad: Amino Acids, Peptides and Proteins by Barrett Graham, Davies John

By Barrett Graham, Davies John

ISBN-10: 0854042423

ISBN-13: 9780854042425

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The feasibility of using the Diels-Alder reaction for covalently linking two peptides has been demonstrated202by the sequence of reactions outlined in Scheme 13. Presumably, it would be possible to synthesise cyclic peptides by attaching a diene at one end of a peptide and a dienophile at the other end. Intermolecular reaction might possibly be prevented by having the diene as a detachable linker on an insoluble support. There appears to be considerable possible mileage as an attractive journey to be made.

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Devaky, J . Pept. , 2001,7,641. K. S. Kumar, M. Roice and V. N. R. Pillai, Tetrahedron, 2001,57,3151. E. Lattmann, D. C. Billington, P. Arayarat, H. Singh and M. Offel, Science Asia, 1999,25, 107. S. Leena and K. S. Kumar, J . Pept. , 2001,58, 117. W. C. Chan, S. L. Mellor, G. E. Atkinson, E. L. Fritzen and D. J. Staples, Solidphase Org. , 2001,1,85. J. K. -W. Kim, J. -S. , 2001,42,7443. B. H. -J. , 2001,42,5629. C. Somlai, P. Hegyes, R. Fenyo, G. K. Toth, B. Penke and W. Voelter, 2. , B: Chem.

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Amino Acids, Peptides and Proteins by Barrett Graham, Davies John


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