By Paolo Sassone-Corsi, Yves Christen
Recent years have visible fantastic advances within the box of circadian biology. those have attracted the curiosity of researchers in lots of fields, together with endocrinology, neurosciences, melanoma, and behaviour. through integrating a circadian view in the fields of endocrinology and metabolism, researchers might be capable of show many, yet-unsuspected elements of ways organisms deal with alterations within the atmosphere and next keep watch over of homeostasis. This box is commencing new avenues in our figuring out of metabolism and endocrinology. A panel of the main unique investigators within the box amassed jointly to debate the current nation and the way forward for the sector. The editors belief that this quantity may be of use to these colleagues who can be opting for up the problem to solve how the circadian clock may be unique for the long run improvement of particular pharmacological thoughts towards a couple of pathologies.
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Additional info for A Time for Metabolism and Hormones
In recent work, we have found that clocks in other tissues are required for at least some of the rhythmic cycling in the fat body. Fig. 2 Circadian gene expression in the fat body: The protocol shown was followed to assay circadian gene expression in the fat body. Fat bodies were collected at 2-h intervals over a 48-h cycle in wild type flies and at 4-h intervals in flies lacking a fat body clock. Several classes of genes were found to cycle Microarrays 38 A. Sehgal A Restricted Feeding Paradigm Resets the Phase of Cyclic Gene Expression in the Fat Body but not in the Brain The genes expressed cyclically in the fat body fall into many different functional categories, including lipid synthesis (in particular, fatty acid elongation), lipid breakdown, steroid hormone metabolism and immune function.
Nature 480:552–556 Li B, Carey M, Workman JL (2007) The role of chromatin during transcription. Cell 128:707–719 Liu AC, Welsh DK, Ko CH, Tran HG, Zhang EE, Priest AA, Buhr ED, Singer O, Meeker K, Verma IM, Doyle FJ 3rd, Takahashi JS, Kay SA (2007) Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell 129:605–616 Lowrey PL, Takahashi JS (2000) Genetics of the mammalian circadian system: photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation.
Histone H3K4me3, H3K9ac and H3K27ac are enriched at promoters and show robust circadian rhythms in occupancy at the Dbp gene. When examined across the genome, we found that circadian rhythms in RNAPII occupancy as well as histone H3K4me3, H3K9ac and H3K27ac modifications occurred in the majority of expressed genes, even in cases where cycling RNA could not be detected. Thus a third surprise in this work was the observation that chromatin states were being modulated in a circadian manner across the genome in the liver.
A Time for Metabolism and Hormones by Paolo Sassone-Corsi, Yves Christen